Modeling of enzymatic processes in the duodenum to predict areas with elevated risks of functional disorders

The present work focuses on developing a model of the duodenum considering motility, biochemical reactions occurring under effects produced by secreted digestive juices, and absorption reaction products in normal conditions case functional disorders. Analysis literature sources allowed identifying basic bile components pancreatic intestinal juice enzymes influencing fats, proteins carbohydrates that enter duodenum. paper provides simplified scheme showing how food are transformed allowing for neural-humoral mechanism digestion regulation. Chyme enters is considered homogenous mixture, which changes its composition during chemical reactions. Mathematical tasking includes mass momentum conservation equations multi-component viscous fluid. secretion juices resulting from described with effluents pipe wall layer. peristaltic law movement was applied to describe tract motility; characteristics do not depend mixture. Numeric experiments necessary results hydrolysis 5 % starch solution exposure amylase. Obviously, all amount this well line experimental data. data concentration fields glucose, amylase, at different moments time fluid velocity field. next stage development expected consider components, disorders / motility as influence exerted neural humoral mechanisms. In future, developed can be predict areas elevated risks disorders, ulcer formation, other defects mucosa. This will help physician prescribe personified therapy diet.